Strong pain/ inflammation in headache, neuralgia, dysmenorrhoea, dental, back, rheumatic, arthritic, muscular pain

Precautions:

History GI bleed, ulcer; recent GI surgery; asthma; hepatic, renal, cardiac impairment; mask infection, GI disease; hypotension, hypothyroidism; CNS depression; raised intracranial pressure; head injury; prostatic hypertrophy; tolerance, dependence; elderly; pregnancy, lactation, children < 12 yrs

Adverse Reactions:

GI upset; rash, itching; renal, hepatic dysfunction; headache; dizziness; drowsiness; hearing disturbance; cough suppression, respiratory depression; thrombocytopenia

Interactions:

ACE inhibitors, beta-blockers, diuretics; anticholinergics; anticoagulants; antihypertensives; antiperistaltic antidiarrhoeals; cardiac glycosides; CNS depressants; corticosteroids,; Li; metoclopramide; methotrexate; MAOIs; other NSAIDs, aspirin; other opioid analgesics; probenecid, phenytoin, antidiabetics; CYP2D6 inhibitors eg quinidine, phenothiazines, antipsychotics; tranquillizers, sedatives, hypnotics; zidovudine

Dose:

Adults, children greater than or equal to 12 yrs: initially 2 tabs with fluid, then 1-2 tabs every 4 hrs as necessary, max 6 tabs/24 hrs

Information provided by MIMS Australia. Copyright © 2008